Applications of the Sodium Fluorescein technique

FLUORESCENCE PHOTOGRAPHY

Application	Notes	Reference
Brain tumours	Described in a series of publications the use of sodium fluorescein for looking at abnormal brain tissue. Concluded that the technique was a valuable aid in determining the presence or absence of abnormal brain tissue in needle biopsy material. Found that metastatic tumours and primary tumours took up fluorescein well. In general claimed that the degree of fluorescence appeared to parallel exactly the degree of malignancy.	Moore et al. 1947, 1948, 1950
Brain tumours	Described how photographs of the technique were taken that enabled differentiation between arterial and venous vessels and the blood supply to tumours.	Feindel, Yamamoto & Hodge 1967
Brain, skin and other tumours	Detailed examination of the fluorescein photographic procedures for the brain tumour work described above.	Hodge1978

Feindel, W., Yamamoto, Y. and Hodge, C., 1967, "Intracarotid fluorescein angiography," Can. Med. J. 96 (1):1-7.
Hodge, C., 1978, "Fluorescein angiography of the brain - the photographic procedure," J. Biol. Photogr. 46(2):67- 79.
Moore, G., Kohl, D., Marvin, J. and Caudill, C., 1950, .'Biophysical studies of methods utilizing fluorescein and its derivatives to diagnose brain tumours," Radiology 55:344-362.